NIH R01 · 2025
Genetic Regulation of Cochlear Duct Patterning and Prosensory Formation
PROJECT SUMMARY Sensorineural deafness is typically caused by the irreversible loss of the inner ear hair cells (HCs). Currently, there is no treatment available to reverse the loss of HCs. Recent advance in regenerative medicine offers promise in treating sensorineural deafness through HC regeneration. Elucidating the molecular mechanism underlying the formation of the inner ear HCs will aid our effort to regenerate HCs and restore hearing. During early cochlear development, the partially overlapping expression of GATA3, ISL1, ISL2, and their negative regulators, LMO3 and LMO4, suggests a novel model for the regulation of cochlear duct patterning and sensory formation, in which the…
From the public funding record at NIH RePORTER. Describes the funded project, not the reviews below.