NIH R01 · 2025
PROJECT SUMMARY Spatially resolved ‘omics techniques have been instrumental in describing the heterogeneity in molecular content in tissues. However, these methods can only provide static measures of the variation in content and fall short on relating how this molecular heterogeneity results in differences in tissue function. Our laboratories have developed a unique functional Mass Spectrometry Imaging (fMSI) method that can measure tissue perfusion and metabolic activities at high spatial resolution and can provide a critical link between spatially resolved ‘omics data and cellular phenotype. This fMSI method uses timed infusions of isotopologues of a single substrate prior to tissue…
From the public funding record at NIH RePORTER. Describes the funded project, not the reviews below.