NIH R01 · 2024
Collaborative Research: EDGE FGT: DEVELOPMENT OF FUNCTIONAL GENETIC TOOLS IN GECKOS
Functional genomic tools, such as CRISPR/cas genome editing, are critical for investigating the biology of genes and have transformed our understanding of genotype-to-phenotype relationships. However, the limited number of species with genome modification methods presents a major bottleneck in implementing comprehensive, comparative studies of gene function. For instance, squamates (lizard and snakes) include more than 11,000 described species and comprise 40% of all amniote species. Yet basic gene editing methods are only available in a single species, the brown anole lizard (Anolis sagrei). Here, we propose to: 1) establish CRISPR/cas gene editing in a second lizard group, the geckos; 2)…
From the public funding record at NIH RePORTER. Describes the funded project, not the reviews below.