NIH R01 · 2024
Role of FABP5 in COPD Exacerbations
PROJECT SUMMARY Inflammation underlies the pathogenesis of many chronic lung diseases. Thus, defining mechanisms by which pulmonary inflammation is regulated and resolved is of high clinical importance. Understanding those mechanisms is especially relevant to chronic obstructive pulmonary disease (COPD), a condition that typically develops following decades of cigarette smoking (CS) and in which repeated respiratory infections are linked to non-resolving inflammation and can cause disease flares (COPD exacerbations). Lung macrophages are critical for both initiation and resolution of inflammation, and the control of exacerbations. They can adopt different phenotypes (i.e., pro-inflammatory…
From the public funding record at NIH RePORTER. Describes the funded project, not the reviews below.