NIH R01 · 2024
Cholinergic interneuron D2 receptor function in impulsive behavior: implications for addiction
Project Summary Chronic cocaine abuse is associated with long-lasting impairments in impulse control and decision-making that increase the risk for relapse. However, the brain circuits fundamentally involved in impulsive behavior and their alteration by chronic drug use are not well understood. Accumulating evidence in humans and animals implicates nucleus accumbens (NAc) dopamine D2 receptors (D2Rs), yet given their wide expression in different neuronal populations, it remains unclear which D2Rs play a key role in impulsive behavior. In particular, the contributions of D2Rs in cholinergic interneurons (CINs), which constitute only 2-3% of neurons in the NAc, have been largely overlooked,…
From the public funding record at NIH RePORTER. Describes the funded project, not the reviews below.