NIH R01 · 2025
The Role of HIV Proteins in Psychostimulant Abuse
Project Summary: The use of amphetamine (AMPH) and its derivatives (e.g. methAMPH) has been linked to human immunodeficiency virus (HIV) transmission1, as HIV can spread through heightened unprotected sexual activity2, 3 that is associated with AMPH use disorder (AUD) 5, 6. For these and other reasons, AMPH dependence and HIV infection have been termed a double epidemic7. In this bidirectional relationship, the role played by AUD in synergizing HIV dependent neurodegeneration is well documented. For example, AUD exacerbates HIV impairments of central dopamine (DA) neurotransmission8-10. Furthermore, the HIV trans-activator of transcription regulatory protein Tat1-86 (Tat) and AMPH act in…
From the public funding record at NIH RePORTER. Describes the funded project, not the reviews below.