NIH R01 · 2025
Mapping Synaptic Density in Prodromal and Manifest Lewy Body Dementia
Project Summary Synaptic loss is theorized to occur early in the course of common neurodegenerative proteinopathies such as Alzheimer disease (AD) and Lewy body dementia (LBD). Until recently, the evaluation of synaptic loss in the human brain depended on the availability of pathologic/autopsy material, which inevitably did not represent early stages of disease. In the past few years, development of radiopharmaceuticals that target SV2A, a ubiquitous synaptic protein, have made it possible to quantify synaptic density in the human brain in vivo. One long-term goal of the collaborative neuroimaging programs at UW-Madison is to use magnetic resonance imaging (MRI) and Positron Emission…
From the public funding record at NIH RePORTER. Describes the funded project, not the reviews below.