NIH R01 · 2024
Connecting TDP-43 Pathology to the Molecular Profiles of Neurodegeneration
Connecting TDP-43 Pathobiology to the Molecular Profiles of TDP-43 Driven Common Dementias In previous collaborative work[1], Dr. Phatnani and Dr. Gale-Hammell used a large ALS patient sequencing consortium to uncover the predominant molecular pathways that are altered in the frontal and motor cortex of patients with this TDP-43 associated disease. In this work, ALS cortex samples could be differentiated into 3 distinct groups based upon whether their transcriptional profiles showed hallmarks of: oxidative stress, retrotransposon de-silencing, or neuroinflammation. Histological staining of tissues from these same patients showed tight links between TDP-43 proteinopathy and the latter two…
From the public funding record at NIH RePORTER. Describes the funded project, not the reviews below.