NIH R01 · 2024
Molecular Determinants for In vivo Functional Reprogramming of Cortical Output Neurons and Circuits
PROJECT SUMMARY/ABSTRACT Currently there is no successful treatment that restores damaged brain circuitry. Neuron loss by either neurodegenerative diseases or trauma causes neurological and cognitive dysfunction, posing a great burden for human health. There is a critical need to find strategies for neural circuit repair. Direct reprogramming approaches hold great promise for brain repair. Their success in functional circuit restoration will depend on their capacity to convert other cells into neurons with functions matching those of the neurons damaged in a circuit. This precise conversion has been observed in the mouse cerebral cortex between cortical output (corticofugal) neurons, which…
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