NIH R01 · 2025
" Investigating the Protective Efficacy of SIV/HIV T and B cell Immunity Induced by RNA Replicons.”
Modified Project Summary/Abstract Section The development of a prophylactic vaccine for HIV would benefit from the generation of immunogens and vaccine delivery modalities that can induce a combination of highly functional CD8+ T cell responses towards mutation constrained epitopes and broadly neutralizing antibody responses to the HIV envelope trimer. Thus, in this proposal, we plan to leverage several components towards this goal: an approach known as structure-based network analysis that was used to identify a set of protective epitopes preferentially targeted by CD8+ T cell responses in spontaneous HIV controllers, 2) an envelope trimer that is capable of eliciting heterologous…
From the public funding record at NIH RePORTER. Describes the funded project, not the reviews below.