Gregory Lab

Research focus

NIH R01 · 2024

Osteoinductive Nanosilicate-Based Biomaterials for In Situ Craniomaxillofacial Bone Regeneration

PROJECT SUMMARY A range of synthetic bone graft substitutes loaded with therapeutic growth factors, such as recombinant human bone morphogenetic protein 2 (rhBMP2), are used for reconstructing craniofacial bone defects in patients suffering from trauma, infection, congenital anomalies, and oncologic resection. However, these strategies often involve the administration of supraphysiological doses of growth factors, which have been reported to lead to serious off-target tissue responses, including heterotopic ossification (bone formation at undesirable places), osteolysis, and swelling. The objective of this proposal is to design osteoinductive biomaterials to induce in situ bone regeneration…

From the public funding record at NIH RePORTER. Describes the funded project, not the reviews below.