NIH R01 · 2024
Dynamics of activity-induced transcription in single dentate granule cells
Project Summary In brain regions involved in learning and memory, a subset of neurons active in response to a novel experience is critical for encoding and later recalling a memory of that experience. These neurons, known as engram cells, have been identified as vital contributors to memory function in areas such as the hippocampus. Studies of engram cells have overwhelmingly used immediate-early gene (IEG) protein products to segregate active from inactive cells. Yet, the downstream processes that allow IEG-expressing cells to encode memories in a way that makes them selective to a particular event remain unknown. Single-nuclei RNA-Seq (snRNA-Seq) now offers an opportunity to reveal…
From the public funding record at NIH RePORTER. Describes the funded project, not the reviews below.