Gaffney Lab

University of Colorado Denver

INTERNAL MEDICINE/MEDICINE

Aurora · United States

NIH-funded
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NIH R01 · 2025

Influence of Prosthetic Foot Stiffness on Transtibial Osseointegrated Bone-Anchored Limb Outcomes

PROJECT SUMMARY The overarching goal of this proposal is to determine the influence of prosthetic foot stiffness on multi- domain loading-related outcomes in individuals with transtibial (TT) bone-anchored limbs (BALs) (i.e., osseointegrated prostheses). BALs are a promising alternative to socket prostheses that have shown to improve overall mobility, physical function, and health-related quality of life. To facilitate positive outcomes, proper load sharing between the implant and bone is pivotal for the mechanobiology of osseointegration at the bone-implant interface, which is directly dependent on loads transferred from the ground to the residual limb. While originated for transfemoral…

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