NIH R01 · 2024
Intracellular pattern formation
PROJECT SUMMARY/ABSTRACT We will investigate how cytoskeletal organelles organize into patterns in the cell. The fields of motile cilia in epithelial cells and the rows of stereocilia in the inner hair cells are examples of physiologically- important organelle patterns. The known pathways do not satisfactorily explain how organelle patterns form. The ciliated protists (ciliates) assemble unusually complex surface (cortical) patterns. Ciliates faithfully duplicate their cortical pattern during cell division and, despite its complexity, the cortical pattern remains nearly invariable in a population. Thus, even subtle deviations from the normal pattern (e.g. due to a mutation or trauma) can be…
From the public funding record at NIH RePORTER. Describes the funded project, not the reviews below.