NIH R01 · 2025
PROJECT SUMMARY Pancreatic beta cell mass is critical for glucose homeostasis and mutations that impact beta cell mass can lead to neonatal or adult-onset diabetes. The parent project aims to understand the signaling and transcriptional control of pancreatic and beta cell development with the hopes of better understanding rare diseases such as pancreas agenesis and leveraging this knowledge to establish how beta cell development could impact diabetes disease progression. This supplement will test the hypothesis that non-coding single nucleotide polymorphisms (SNP)s associated with type 2 diabetes (T2D) can act via modulation of pancreatic development, leading to decreased beta cell mass.…
From the public funding record at NIH RePORTER. Describes the funded project, not the reviews below.