NIH R01 · 2025
Utility of human milk oligosaccharides against the perinatal pathogen, Group B Streptococcus
Project Summary Adverse pregnancy outcomes are a global issue that affects more than 50 million people per year. Infections during gestation contribute significantly to adverse pregnancy outcomes, such as preterm birth and neonatal sepsis. Streptococcus agalactiae or Group B Streptococcus (GBS) is a major cause of ascending vaginal and intrauterine infection during pregnancy. To initiate infection, GBS must colonize the vagina and initiate a robust biofilm to turn the vaginal mucosa into a replicative niche. Subsequently, GBS ascends the reproductive tract in an undefined process to invade the gestational membranes, cross the placenta, and infect the amniotic cavity and the fetus.…
From the public funding record at NIH RePORTER. Describes the funded project, not the reviews below.