Gabriel Lab

University of Alabama at Birmingham

PUBLIC HEALTH & PREV MEDICINE

Birmingham · United States

NIH-funded
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NIH R01 · 2024

Determining true versus apparent treatment-resistant hypertension among African Americans in the Jackson Heart Study

Abstract African Americans (AAs) have a high prevalence of hypertension and suffer a disproportionately high risk for cardiovascular disease compared to whites. Apparent treatment-resistant hypertension (aTRH) is a severe form of hypertension defined as requiring ≥ 4 antihypertensive medications to achieve blood pressure (BP) control. An estimated 9 million US adults have aTRH. Given the rigorous clinical work-up needed to rule out pseudoresistance and therefore, diagnose true TRH, the population prevalence of TRH is not known. We propose an ancillary study to the Jackson Heart Study (JHS), a large prospective cohort of AA adults (n=5,306) that will deeply phenotype participants with aTRH,…

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