NIH R01 · 2025
Sperm chromatin structure and remodeling during spermiogenesis and fertilization
PROJECT SUMMARY Genetic inheritance material of a eukaryotic organism (DNA) is stored in chromosomes. Understanding of cellular activities in normal development and disease requires the analyses of critical regulatory roles that are played by packaging the genome into a nucleoprotein complex termed chromatin. The structure of chromatin and the regulatory machinery of its metabolism are uniquely important and thus, strongly conserved in evolution. The objective of our work is to understand the relationship between the establishment of chromatin structure in the male gametes (sperm cells) and regulation of their function. We will focus on a systematic study of sperm chromatin structure and…
From the public funding record at NIH RePORTER. Describes the funded project, not the reviews below.