NIH R01 · 2025
Molecular Mechanisms Underlying the sex-Depended Maturation of Modulatory Systems.
PROJECT SUMMARY/ABSTRACT Males are diagnosed with autism spectrum disorder (ASD) at least four times as frequently as females, but the molecular underpinnings of male predominance remain elusive. Serotonergic (5-HT) neurons in the raphe nuclei (RN) extend axonal projections throughout the brain and regulate many essential brain function, including social behaviors. Importantly, abnormal development of the 5-HT system has been described in ASD. 5-HT signaling in the brain differs in males and females, but molecular mechanisms regulating sex-dependent 5-HT synaptic function are largely unknown. The overarching goal of this proposal is to elucidate molecular mechanisms underlying sex-dependent…
From the public funding record at NIH RePORTER. Describes the funded project, not the reviews below.