NIH R01 · 2024
Structure and Function of Hetero-Multimeric Ligand-Gated Ion Channels
Project Summary The primary objective of this project is to gain a comprehensive understanding of the structures and functions of N-methyl-D-aspartate receptors (NMDARs), which play critical roles in brain functions and development. NMDARs belong to the ionotropic glutamate receptor (iGluR) family, which mediates the majority of excitatory synaptic transmission in mammalian brains. Dysfunctional NMDARs are implicated in neurological disorders and diseases, including Alzheimer’s disease, depression, stroke, schizophrenia, and seizure. They are hetero- tetrameric ligand-gated ion channels comprised of GluN1 and GluN2 and/or GluN3 subunits. The GluN1 and GluN3 subunits bind to glycine, while…
From the public funding record at NIH RePORTER. Describes the funded project, not the reviews below.