NIH R01 · 2025
Multi-omic characterization of genetic variants in IBD risk loci
PROJECT SUMMARY/ABSTRACT The NIDDK IBD Genetics Consortium (IBDGC) has led Genome-wide association studies (GWAS) that have determined >250 genomic loci associated with IBD. The vast majority of these loci, which can contain hundreds of variants, are in non-coding regions enriched for regulatory elements. As a result, determining both the casual variant and the mechanism by which this variation contributes to IBD is not known for most. A primary goal of this IBDGC Ancillary RFA is to fill this gap. In line with this goal, we hypothesize that most IBD GWAS loci contribute to disease by altering activity of regulatory elements defined by accessible, chemically modified chromatin resulting in…
From the public funding record at NIH RePORTER. Describes the funded project, not the reviews below.