NIH R01 · 2025
Mechanisms of pterin-dependent regulation in proteobacterial systems
PROJECT SUMMARY The transition of bacteria from a free-living state to a sessile, surface-attached growth mode often leads to formation of multicellular biofilms, profoundly altering cellular physiology and increasing antimicrobial tolerance. Attachment and biofilm formation is regulated in many systems by the pivotal cytoplasmic second messenger cyclic diguanylate monophosphate (c-di-GMP), with high levels commonly promoting adherence and low levels favoring planktonic growth. Recent work has identified a remarkable regulatory circuit that controls intracellular c-di-GMP levels through the activity of excreted metabolites called pterins. Diguanylate cyclases (DGCs) synthesize c-di-GMP from…
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