NIH R01 · 2025
Active chromosome movement in meiotic pairing
PROJECT SUMMARY Homologous chromosome pairing during meiosis is a central process underlying Mendelian inheritance, in which homologous chromosomes move through the nuclear interior to locate and pair with their homologs, prior to synapsis via the assembly of the synaptonemal complex (SC). Failure of this pairing process can result in aneuploidy. Much of the effort to understand meiosis has focused on determining genes involved in homology recognition and recombination, but the physical process by which chromosomes come together inside the densely packed nucleus remains poorly understood. In order to pair successfully, chromosomes must carry out a huge number of homology tests while…
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