NIH R01 · 2024
Developmental programs as vulnerabilities in H3.3G34-mutant high-grade glioma
Abstract/Project Summary Brain tumors are the leading cause of cancer-related deaths among children. Recent studies have identified new subtypes of brain tumors, including high-grade glioma with G34R/V mutations in the histone variant H3.3 (HGG-G34). This subtype primarily affects the cerebral hemispheres of adolescents and young adults. In addition to the histone mutation, HGG-G34 often exhibits mutations in both ATRX and TP53. However, the precise pathogenic mechanism of HGG-G34 remains poorly understood. Currently, there are no established therapeutic approaches tailored to this subtype, and patients continue to face a dismal prognosis. Therefore, there is an urgent clinical need to…
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