NIH R01 · 2024
Molecular-Genetic Dissection of Subcortical Circuitry Regulating Arousal
Project Summary There is a fundamental gap in understanding the circuit, cellular and synaptic bases by which the brain regulates and maintains neurobehavioral and electroencephalographic (EEG) arousal. This is an important problem because it not only reduces our ability to treat disorders of arousal, including restoration of consciousness in comatose individuals, but also impacts treatment and deeper understanding of many neuropsychiatric, neurodegenerative and neurological disorders that often include severe arousal disruption, including Alzheimer’s and Parkinson’s disease. We recently uncovered an especially critical and unexpected role for basal forebrain GABAergic (BFGABA) neurons in…
From the public funding record at NIH RePORTER. Describes the funded project, not the reviews below.