NIH R01 · 2025
PROJECT SUMMARY Head and neck cancers (HNCs) afflict over 65,000 Americans annually, with survivors often battling lingering complications from treatments like surgery, radiation, and chemotherapy. Notably, lymphedema and fibrosis emerge as prevalent post-treatment issues. Post-radiation inflammation triggers a cascade—from potentially reversible soft tissue edema and lymphedema to, more worryingly, permanent fibrosis. About 75% of radiated patients manifest lymphedema signs within three months, and between 30-50% evolve into moderate-to-severe neck fibrosis. This progression severely impacts functions like swallowing, speech, and neck movement. The diagnostic landscape currently leans…
From the public funding record at NIH RePORTER. Describes the funded project, not the reviews below.