NIH R01 · 2024
A Novel Neural Mechanism that Mediates the Therapeutic Effects of Metformin
Metformin is the most prescribed first-line anti-diabetic drug. It has been widely accepted that metformin lowers blood glucose primarily by reducing glucose output in the liver, and to a lesser extent by increasing peripheral glucose uptake. However, exactly how metformin can do so remains controversial and debated. The brain has (re)emerged as an important regulator of whole-body glucose metabolism. The central nervous system (CNS) is known to regulate glucose output and glucose uptake in the peripheral tissues, thereby changing whole-body glucose balance. We previously found that the small GTPase Rap1 in the brain or in the hypothalamus strongly influences glucose balance without…
From the public funding record at NIH RePORTER. Describes the funded project, not the reviews below.