NIH R01 · 2024
Fortilin, CTNNA3, and the Heart
Project Summary The main goal of this grant proposal titled “Fortilin, CTNNA3, and the Heart” is to test the central hypothesis that the inability of the failing heart to maintain fortilin expression leads to decreased CTNNA3 transcription, increased CTNNA3 protein degradation, and lethal heart failure (HF). Nearly 6 million Americans live with HF, with about 670,000 new cases diagnosed each year. HF is a relentlessly progressive disease that is associated with an unacceptably high death rate—about 40% of patients with severe HF die within a year. The attempts to slow HF progression by overexpression of sarcoplasmic reticulum calcium ATPase (SERCA2a), stromal cell-derived factor-1 (SDF-1),…
From the public funding record at NIH RePORTER. Describes the funded project, not the reviews below.