NIH R01 · 2024
Privileged and primitive hematopoietic stem cells, niches, and regulatory T cells
Although hematopoietic stem cells (HSCs) have been extensively studied in transplantation and cancer, immunological properties of the HSC niche have remained largely unexplored. The testis and placenta act as immunological sanctuaries for embryonic and germline stem cells, and are termed immune privileged sites. In these tissues, allogeneic (allo-) or xenogeneic grafts persist long-term, even without immune suppressive therapy. Little is known about whether tissue-committed stem cell niches are broadly immune privileged. Our current R01 has tested whether the HSC niche within the bone marrow (BM) acts as an immune privileged site that shields both allo-HSCs and leukemic stem cells (LSCs)…
From the public funding record at NIH RePORTER. Describes the funded project, not the reviews below.