NIH R01 · 2024
Regulation of Eye Morphogenesis
Project Summary Congenital ocular malformations such as microphthalmia, anophthalmia and coloboma are prevalent in 1 in 3- 4,000 individuals and are the cause for over 25% of childhood blindness worldwide. Defective closure of the optic fissure (coloboma) alone may account up to 10% of childhood blindness. Therefore, it is vitally important to understand the molecular mechanisms underlying ocular development. While several causative genes are identified, more effort is required to define the downstream targets and events underlying eye morphogenesis. In our previous project, we showed that Porcn signaling needs to be tightly regulated during optic cup formation and optic fissure closure.…
From the public funding record at NIH RePORTER. Describes the funded project, not the reviews below.