Demartini Lab

Yale University

PSYCHIATRY

New Haven · United States

NIH-funded
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NIH R01 · 2025

Deep Phenotyping of Heavy Drinking in Young Adults with Behavioral Scales, Neuropsychological Tasks, and Smartphone Sensing Technology

ABSTRACT Alcohol use disorder (AUD) reaches peak levels during young adulthood, making it critical that we understand person-specific alcohol risk profiles in young adults to prevent AUD or intervene before this disorder becomes chronic. The National Institute on Alcohol Abuse & Alcoholism’s (NIAAA) neurobiological framework, the Addictions Neuroclinical Assessment (ANA), offers an innovative approach for understanding AUD in this population. The ANA posits that individual differences in 3 neurofunctional domains can help differentiate the substantial clinical heterogeneity in AUD. The ANA builds upon the NIMH Research Domain Criteria (RDoC), a dimensional framework for investigating mental…

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