NIH R01 · 2024
Type I Interferon Pathway in Pancreatic Adenocarcinoma
ABSTRACT Chronic pancreatitis provides proliferative advantage to oncogene-harboring pancreatic cells, shields transformed cells from anti-tumor factors, and stimulates the metastatic process. Accordingly, pancreatic inflammation emerges as an important factor in the development and progression of pancreatic ductal adenocarcinoma (PDA), which is a lethal disease with low survival rate. A better understanding of the anti- tumorigenic targets of pancreatic inflammation is critical for developing novel approaches to efficient therapies. In proposed here studies, we focus on the importance of type I interferons (IFN1) cytokines that act through IFNAR1 receptor to elicit a cell-autonomous tumor…
From the public funding record at NIH RePORTER. Describes the funded project, not the reviews below.