NIH R01 · 2025
Characterization of structure-function relationships in distinct thalamic reticular nucleus networks
PROJECT SUMMARY Nearly all sensory information destined for the neocortex is relayed through the thalamus. The thalamic reticular nucleus (TRN), a thin shell of GABAergic neurons surrounding the dorsal thalamus, receives both collaterals from cortico-thalamic and thalamo-cortical glutamatergic inputs, but exerts its unidirectional powerful inhibition only to the thalamus. TRN thus is considered as a master controller of thalamo-cortical circuits regulating the flow of the information between thalamus and neocortex. Perturbed TRN function may underlie behavioral deficits in disorders ranging from schizophrenia, ADHD and autism. Although the importance of the TRN has long been recognized, our…
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