NIH R01 · 2024
The relationship between neuronal activity and stroke
Stroke is the one of the leading causes for death and the leading cause of long-term disability in the USA, and most strokes originate from blood flow blockage known as ischemic stroke. Since the majority of cortical ischemic strokes originate from blockage in the middle cerebral artery (MCA), our lab has studied stroke protection in a rat model of permanent middle cerebral artery occlusion (pMCAo). Our findings have demonstrated that sensory stimulation in the early 2 hours following pMCAo is protective but later (3-4 hours) the same stimulation becomes damaging (known as infarct). It is assumed that the location and volume of either the damaged or protected territory depends on the…
From the public funding record at NIH RePORTER. Describes the funded project, not the reviews below.