NIH R01 · 2025
Iterative Cyclization Strategies for Complex Molecule Synthesis
Project Summary/ Abstract In order to do a better job identifying complex molecules with novel bioactivity and suitable bioavailability profiles, chemists need a larger supply of promising small molecules, which requires new methods for their efficient synthesis. However, there are many molecules of interest, both natural and non-natural, that are still difficult to prepare with high efficiency and selectivity. Synthetic chemists are constantly searching for versatile new methods for building densely functionalized molecules that contain vicinal chiral centers and quaternary centers. The development of efficient, stereoselective carbon-carbon bond-forming methods will enable chemists to…
From the public funding record at NIH RePORTER. Describes the funded project, not the reviews below.