NIH R01 · 2024
A2: Striosomal models of drug use and cost
Project Summary Our understanding of the mechanistic underpinnings of drug consumption and craving has been greatly aided by the development of numerous computational models focused on these behaviors. However, most of these models ignore the role of cost. To this end, our proposal seeks to experimentally validate a novel computational neurobiological model of costly drug-taking behavior centered on the striosomes of the dorsomedial striatum (DMS). Notably, the striosomes lie at the center of the cortico-striatal- dopaminergic circuit, which is critical for drug-seeking behavior and the evaluation of co- occurring cost and reward. While DMS striosomes have been implicated in behaviors such…
From the public funding record at NIH RePORTER. Describes the funded project, not the reviews below.