NIH R01 · 2025
Project Summary/Abstract Autoimmune hemolytic anemia (AIHA) is a severe hematologic disorder caused by the antibody-mediated destruction of red blood cells (RBCs). The disease causes significant morbidity and mortality for patients: With today's treatments, patients face a significant risk of death, high relapse rates, and only a rare chance at full remission. Better therapies are possible, but our limited understanding of the genetic and immunologic mechanisms that lead to AIHA are roadblocks to making new treatments a reality. Fortunately, dogs provide an exceptional naturally occurring model for studying genetic risk factors and T cell biology in AIHA. The disease is naturally occurring…
From the public funding record at NIH RePORTER. Describes the funded project, not the reviews below.