NIH R01 · 2024
Fine-grained Annotation of the Protein Universe through a Community of Practice
PROJECT SUMMARY The functional annotation of proteins is a major bottleneck of biological discovery in the post-genomic era. We are able to accurately generate large swaths of genomic and metagenomic sequence data. We are also able, to a lesser extent, to assemble those sequences correctly, and identify open reading frames. Our capability to accurately generate biological knowledge from genomic data drops precipitously at the third step: assigning the biological function to proteins. The Critical Assessment of Functional Annotation, or CAFA is a computational challenge that involves a community of computational biologists, data scientists, ontologists, and biocurators working together to…
From the public funding record at NIH RePORTER. Describes the funded project, not the reviews below.