NIH R01 · 2025
Neurobiological mechanisms of altered cortical plasticity in Type-2 diabetes mellitus
PROJECT SUMMARY Nearly 25% of Americans aged 65 and older have Type-2 diabetes mellitus (T2DM) and more than half have elevated hemoglobin A1c indicating impaired glucose tolerance, or prediabetes. T2DM can affect the brain through neuronal toxicity of hyper- and hypoglycemia episodes, microvascular insults, impaired glucose transfer and insulin resistance. The neurologic impact of T2DM is widespread and can lead to structural, functional, and metabolic brain changes. Clinically, T2DM is associated with faster cognitive decline and a higher risk of dementia, including Alzheimer’s disease (AD). The link between T2DM-associate brain changes and cognitive decline is not completely understood,…
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