Freytes Lab

North Carolina State University Raleigh

ENGINEERING (ALL TYPES)

Raleigh · United States

NIH-funded
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NIH R01 · 2025

Non-invasive Therapy using Lamina Propria Extract for Vocal Fold Healing

PROJECT SUMMARY To address the public health issue of voice disorders affecting approximately 20 million Americans annually due to vocal fold (VF) scarring and laryngotracheal injuries, this project focuses on a non-invasive, innovative treatment strategy. Utilizing a specially derived Vocal Fold Lamina Propria extract (VFLPx), which has demonstrated promising results in reducing fibrotic gene expression, the proposed project aims to fine-tune the dosage and application methods of VFLPx. The research is structured around three principal objectives: (1) To conduct a detailed investigation into the anti-fibrotic and anti-microbial properties of VFLPx through advanced proteomic analysis and…

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