NIH R01 · 2024
PROJECT SUMMARY Exposure to environmental toxicants including pesticides causes dopamine (DA) neuron loss in the substantia nigra (SN) and raises risk for developing Parkinson’s disease (PD). Toxicant exposure studies show sexually dimorphic DA neuron resilience, such that females lose fewer DA neurons than males. This sex difference is relevant since PD in women is less prevalent and has a later age of symptomatic onset. However, the mechanisms for these sex differences in DA neuron resilience to toxicants remain poorly understood. We have leveraged the respective advantages of fly and rodent models of DA neurodegeneration to provide new insights into toxicants’ effects on selective DA…
From the public funding record at NIH RePORTER. Describes the funded project, not the reviews below.