NIH R01 · 2024
Ribonucleotide Processing in Telomere Maintenance and Integrity
Abstract Chromosomal ends harbor repetitive DNA sequences, termed telomeres, that are recognized by the shelterin complex to form a lariat structure called the T-loop, which protects vital genetic information and prevents erro- neous DNA double strand break repair. Each cell division these telomeres are shortened until they reach a crit- ically short length, causing cellular apoptosis or senescence. This shortening can be counteracted by the ribo- nucleoprotein telomerase, which functions to maintain telomere integrity by elongating the 3’ end of telomeres. Because of this fundamental role played by telomerase, about 85 - 90% of all cancers upregulate telomerase to lengthen telomeres and…
From the public funding record at NIH RePORTER. Describes the funded project, not the reviews below.