Fregni Lab

Spaulding Rehabilitation Hospital

Charlestown · United States

NIH-funded
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NIH R01 · 2025

Pragmatic Trial of Remote tDCS and Somatosensory Training for Phantom Limb Pain with Machine Learning to Predict Treatment Response

PROJECT SUMMARY/ABSTRACT: Phantom limb pain (PLP) is considered an extremely hard-to-treat disorder, given that traditional treatments are not effective in targeting the maladaptive neuronal circuits associated with chronic pain. Transcranial direct current stimulation (tDCS) is a non-invasive, safe brain stimulation technique that has been shown to revert maladaptive plasticity as well as reduce pain in neuropathic pain and other pain syndromes. Our previous R01 on this topic has demonstrated the efficacy of tDCS combined with somatosensory training in a controlled setting to improve pain and that this intervention changes PLP associated cortical plasticity. Our previous R01 also shown…

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