NIH R01 · 2025
New Congenital Disorders of Glycosylation: Therapy and Models
PROJECT SUMMARY AIM1 studies how a therapeutic sugar is mobilized for glycosylation. Sugars taken up from outside the cell are handled differently than those produced inside the cell. We found that activated fucose (GDP-Fuc) exists in multiple cytoplasmic pools that differentially contribute to glycosylation., There is no homogenous, feely mixing pool of sugars. This segregation requires a previously unimagined level of cellular organization to distinguish fucose from different origins. We measured simultaneous contributions of the de novo, exogenous, and recycled (salvaged) fucose into multiple glycoproteins. Their contributions varied based on the fucose origin, glycoprotein acceptor,…
From the public funding record at NIH RePORTER. Describes the funded project, not the reviews below.
← All labs at Sanford Burnham Prebys Medical Discovery Institute