NIH R01 · 2025
Retinal Pigmented Epithelium Epigenome Dysregulation With Aging and Modulation by Diet
Abstract/Summary Aging is the principal risk factor for age-related macular degeneration (AMD), a neurodegenerative disease characterized by the irreversible loss of vision. Clinical and mouse studies indicate that consumption of diets with higher dietary glycemic indices increase AMD risk. Atrophy of the retinal pigmented epithelium (RPE) layer is an AMD hallmark that precedes photoreceptor cell loss. However, the mechanisms underlying RPE impairment with aging and exacerbation by poor diet are unclear. Thus, therapeutic approaches to maintain RPE function with aging and prevent AMD are yet to be developed. Epigenetic processes (DNA modifications and chromatin accessibility) in the RPE may…
From the public funding record at NIH RePORTER. Describes the funded project, not the reviews below.