NIH R01 · 2025
Racial Difference in Prostate Cancer
SUMMARY Men of West African ancestry (AA) in the United States have the highest risk of prostate cancer (PC) globally, and AA men frequently present with more aggressive disease. In the previous funding period, our goal was to identify master transcription factors (MTFs) that function more often in AA in comparison to EA PC. The competitive renewal project is based on our discovery of a novel interaction between Kaiso, an AA-associated TF, and ONECUT2 (OC2), a race-independent TF. Both of these MTFs are established malignancy drivers. Importantly, we have demonstrated that OC2 is directly targetable with a novel family of small molecule inhibitors (OC2i) that suppress established CRPC…
From the public funding record at NIH RePORTER. Describes the funded project, not the reviews below.