NIH R01 · 2025
SARM1-mediated mechanisms of axon degeneration
Project summary Nervous system injury activates a complex series of events including axon degeneration, reactive glial responses, and nervous system inflammation. These processes conspire in poorly-defined ways to drive the destruction of axons and synaptic connections, and neuronal death, which ultimately result in neural circuit dysfunction. Our goal is to define molecular pathways that drive neurodegeneration and use that information to block axon and synapse loss in patients. In previous work we identified the TIR domain molecule dSarm/SARM1 (flies/mammals) as a key regulator of axon degeneration after axotomy. In dSarm/SARM1 mutant flies or mice, distal severed axons survive and remain…
From the public funding record at NIH RePORTER. Describes the funded project, not the reviews below.