NIH R01 · 2025
Functions of LynA and LynB kinases in myeloid-cell pro-inflammatory signaling and lupus
ABSTRACT The Src-family kinase Lyn is critical for maintaining immune homeostasis and protecting against autoimmunity, and deficits in Lyn function are linked to systemic lupus erythematosus (SLE). However, cellular studies report conflicting (paradoxical) inflammatory and immunosuppressive functions, varying by cell and perturbation. We have discovered that the two Lyn splice forms (A, B) are differentially regulated, suggesting non-overlapping interactions and roles The apparently paradoxical positive and negative effects might be explained by isoform- specific functions that vary with expression, immune compartment, and environment. We generated single-iso- form LynAKO and LynBKO mice…
From the public funding record at NIH RePORTER. Describes the funded project, not the reviews below.