NIH R01 · 2025
PROJECT SUMMARY/ABSTRACT Transcriptional dysregulation and loss of differentiated cell identity are fundamental cancer traits. Genome-wide analyses have profoundly informed our understanding of these features, allowing investigators to broadly survey tumorigenic alterations, classify tumors, and understand responses to perturbations. While most genome-wide or ‘-omic’ studies have focused on genetics and transcripts, tools and methods have recently matured enabling epigenome-wide studies on clinically annotated primary specimens. The overall goal of this proposal is to utilize the power of innovative epigenomic methods and signatures to inform our understanding of lineage plasticity,…
From the public funding record at NIH RePORTER. Describes the funded project, not the reviews below.