NIH R01 · 2025
Elucidating prostate cancer risk mechanisms through large-scale cistrome wide association studies
PROJECT SUMMARY/ABSTRACT In stark contrast to Mendelian disorders, the majority of complex trait-associated common variants map to non-protein coding regions. Since there is a less well-developed genetic code for the much larger non- protein coding portion of the genome, identifying the gene(s) and causal alleles underlying non- Mendelian/complex traits presents a challenge. Given the rapidity with which genome wide association studies (GWAS) are discovering regions associated with complex traits, causal allele and susceptibility gene identification have become severe bottlenecks. The overall goal of this proposal is to outline a rigorous and comprehensive strategy to discover functionally…
From the public funding record at NIH RePORTER. Describes the funded project, not the reviews below.